Education Experience

• 1994/09-1999/07 Bachelor in Preventive Medicine, Norman Bethune University of Medical Sciences;

• 2001/09-2003/07  Master in Toxicology, Jilin University;

• 2003/09-2006/07  Ph.D in Radiation Medicine, Jilin University;

Working Experience

• 2006/07-2013/09  Lecturer, Department of Toxicology, Jilin University;

• 2010/08-2014/06  Postdoctoral in Public Health and Preventive Medicine, Jilin University;

• 2011/07-2012/07 Visiting Scholar, Analytical & Environmental Toxicology, Division Department of Laboratory Medicine & Pathology, University of Alberta;

• 2013/09-present  Associate Professor, Department of Hygienic Toxicology, School of Public Health, Jilin University;

Research Fields

• Environmental toxicology

• Heavy metal toxicology

• Toxicological safety evaluation

Research Projects

• General Project of National Natural Science Foundation of China, Grant No. 81973089, Research on the death effect and mechanism of Parthanatos induced by silica nanoparticles, 2020/01-2023/12, 540 000￥, in research, second place.

• The Natural Science Foundation Project of Science and Technology Commission of Jilin Province, Grant No.20200201156JC，Bone marrow mesenchymal stem cells repair testicular injury induced by hexavalent chromium through regulating mitochondrion autophagy mediated by MAPK, 2020/01-2022/12, 80 000￥, in research, second place.

• Jilin Provincial Special Project of Industrial Technology Research and Development, Key technologies and products of reconstituted human insulin fusion protein for oral mucosal delivery, 2018/01-2019/12, 250 000￥, completed, second place.

• Special Project for the Pplan Co-sponsored by Jilin Province and University, Grant No.SXGJQY2017-12, Preparation technology and quality control standard of mesenchymal stem cell preparation, 2017/01-2021/12, 2 000 000￥, in research, third place.

• Jilin Provincial Science and Technology Development Program, Grant No.20130413023GH, Repair effect of bone marrow mesenchymal stem cells on intestine mucous injury of serious burned rats by anti-apoptosis, 2013/01-2015/12, 70 000￥, in research, third place.

• The Fundamental Research Funds of Jilin University, Grant No.200903113, Cadmium-induced apoptosis in myocardial cell via caspase-independent pathways, 2009/12-2011/12, 50 000￥, completed, presided over.

• Key Laboratory Project of Department of Health of Jilin Province, Grant No.2008Z030, Study on the mitochondria damage and cell apoptosis of hepatocarcinoma induced by cadmium chloride, 2009/01-2010/12, 15 000￥, completed, presided over.

• Research Fund for the Doctoral Program of Higher Education of China , Grant No.200801831124, Study on Myocardial Ischemia/Reperfusion Injury and Regulation of Calcineurin Signaling Pathway, 2009/01-2011/12, 36 000￥, completed, presided over.

• Transverse Research Project of Changchun Institute of Biological Products Co., Ltd， Grant No.2012677, High density and large-scale cell culture technology of innovative drug incubation (Jilin) polar region, 2012/06-2014/06, 140 000￥, completed, participated in.

• National Natural Science Foundation general project, Grant No. 30771777, Methylmercury induced brain development damage and PKC and CAN mediated negative regulation of cell cycle, 2008/01-2010/12, 280 000￥, completed, participated in.

• National Natural Science Foundation of China for Youths, Grant No.30700672, Research on the apoptosis and mechanismof hepatoma cells induced by cadmium  mediated by the endoplasmic reticulum pathway, 2008/01-2010/12, 170 000￥, completed, participated in.

• Ph.D. Programs Foundation of Ministry of Education of China, Grant No.20090061110062, Effect of nano-SiO2 on human hepatocyte fusion and its toxicological significance, 201001-201212, 60 000￥, completed, participated in.

• Supported by Jilin University Postdoctoral Foundation, Grant No.801101120427, Cytotoxicity and oxidative stress mechanism of halo-benzoquinones in vitro, 2010-2013, 20 000￥, completed, presided over.

• Jilin University Scientific Research Fund, Grant No.419080101427, Study on the anti-tumor effect of cadmium chloride in vivo, 2007-2009, 40 000￥, completed, presided over.

Publications

• Shanshan Hou, Xiayu Zhang, Haiying Du, Xiaofan Ning,Hao Wu, Chunrui Li, Yuxin Liu, Zhiwei Sun, Zhongjun Du, Minghua Jin. Silica nanoparticles induce mitochondrial pathway-dependent apoptosis by activating unfolded protein response in human neuroblastoma cells. Environmental Toxicology, 2020, 1–11.

• Haiying Du, Jinhua Li, Birget Moe, Claire Mcguigan and Xing-Fang Li. A real-time cell-electronic sensing method for comparative analysis of toxicity of water contaminants. Anal. Methods, 2014,6, 2053-2058.

• Wen Wang,*Yang Li,*Xiaomei Liu, Minghua Jin, Haiying Du, Ying Liu, Peili Huang, Xianqing Zhou, Lan Yuan, Zhiwei Sun.. Multinucleation and cell dysfunctioninduced by amorphous silica nanoparticlesin an L-02 human hepatic cell line. International Journal of Nanomedicine, 2013, 8: 3533–3541.

• Haiying Du, Jinhua Li, Birget Moe, Claire F. McGuigan, Shengwen Shen, and Xing-Fang Li*. Cytotoxicity and Oxidative Damage Induced by Halobenzoquinones to T24 Bladder Cancer Cells. Environ. Sci. Technol, 2013, 47 (6):2823-2830.

• Li Yan-bo, Zhang Hai-xia, Guo Cai-xia, Hu Gui-qin, Du Hai-ying, Jin Ming-hua, *Huang Pei-li, Sun Zhi-wei, Yang Wen-sheng. Cytotoxicity and DNA Damage Effect of TGA-capped CdTe Quantum Dots. Chemical Research In Chinese Universities, 2012, 28(2): 276-281.

• DU Hai-ying, WANG Hua, JIN Ming-hua, XU Yan-ling, LI Peng, Sun Zhi-wei*. Mechanism of DNA damage induced by cadmium chloride in rat H9c2 cells. Journal of Jilin University (Medicine Edition), 2011, 37(6): 1044-1047.

• LI Peng, LU Ri-feng, ZHOU Ying-jie, XU Yan-ling, LIN Xin-li, ZHANG Long, DU Hai-ying*. Inhibitory effects of cadmium chloride on human cancer cells and influence in proliferation cell nuclear antigen and metallothionein expressions. Journal of Jilin University (Medicine Edition), 2011, 37(4): 641-645.

• Xing Feng, Jing Li, Jinyu Liu, Minghua Jin, Xiaomei Liu, Haiying Du, Long Zhang, Zhiwei Sun, Xiaoguang Li. .Protective effect of FK506 on myocardial ischemia/reperfusion injury by suppression of CaN and ASK1 signaling circuitry. Cardiovasc Toxicol. 201,11(1):18-27.

• Liping An, Yapei Wang, Xiaomei Liu, Ning Ma, Haiying Du, Minghua Jin, Ying Liu, Long Zhang,Yanling Xu, Peili Huang, Zhiwei Sun*. Block ionomer complex micelles based on the self-assembly of poly(ethylene glycol)-b-poly(acrylic acid) and CdCl2 for anti-tumor drug delivery. Chemical and Pharmaceutical Bulletin. 2011, 59(5): 559-563.

• Yanling Xu, Haiying Du, Minghua Jin, Xiaomei Liu, Long Zhang, Zhiwei Sun*. Inhibitory effects of cadmium chloride on SMMC-7721 cellsin hepatocarcinoma transplanted nude mice and influnce in mitochondrial enzymes. Journal of Jilin University (Medicine Edition), 2011, 37(1): 56-60.

• Liping AN, Yapei WANG, Xiaomei LIU, Ning MA, Haiying DU, Minghua JIN, Ying LIU,Long ZHANG, Yanling XU， Peili HUANG, and Zhiwei SUN. Block Ionomer Complex Micelles Based on the Self-Assembly of Poly(ethylene glycol)-block-poly(acrylic acid) and CdCl2 for Anti-tumor Drug Delivery. Chem Pharm Bull (Tokyo). 2011,59(5):559-63.

• Lei Sun, Wen Wang, Haiying Du, Xiaomei Liu, Minghua Jin, Ying Liu, Zhiwei Sun *. A study on toxicity of liver cell exposed to methylmercury. Journal of Toxicology, 2009, 23(1): 37-39.

• Xiaomei Liu, Ying Liu, Haiying Du, Minghua Jin, Wen Wang, Danbing Peng, Guangyan Yu, Lei Sun, Zhiwei Sun*. Oxidative damage on SMMC-7721 induced by cadmium chloride. Journal of Toxicology, 2008, 22 (5): 337-339.

• Haiying Du, Minghua Jin, Ying Liu, Xiaomei Liu, Wen Wang, Zhiwei Sun *. Study on the Anti-tumor Effect of Cadmium in vivo. Modern Preventive Medicine, 2008, 19(35): 3763-3765.

• Caixia Guo, Yanbo Li, Haiying Du, Ying Liu, Lei Sun, Minghua Jin, Zhiwei Sun*. Effects of over-expressed Smac gene coupling with cisplatin on proliferation and apoptosis of hepatocarcinoma cells. CHINESE JOURNAL OF HEPATOLOGY, 2008, 16(9): 674-677.

• Jianxin Zhang, Minghua Jin, Haiying Du, Xiaomei Liu, Ying Liu, Wen Wang, Zhiwei Sun*. Toxicity of methyl mercury on male mouse germ cells. Journal of Jilin University (Medicine Edition), 2008, 34(5): 767-772.

• Xiaomei Liu, Minghua Jin, Haiying Du, Ying Liu, Wen Wang, Zhiwei Sun*. Synergistical soppressive effect of cadmium chloride and cisplatin on the proliferation of human hepatoma cell line. Carcinogenesis, Teratogenesis & Mutagenesis, 2008, 20(2):100-102.

• Haiying Du, Minghua Jin, Xiaomei Liu, Zhiwei Sun*. Study on the anti-tumor effect of cadmium. International congress of toxicology, 2007, abstract number: PT10.307307.

• Wen Wang, Xiaomei Liu, Haiying Du, Minghua Jin, Lei Sun, Zhiwei Sun*. Compare different detection method on the analysis of DNA damage of SMMC-7721 induced by cadmium. Chinese Journal of Public Health, 2007, 23(10): 1202-1204

• Haiying Du, Xiaomei Liu, Ying Liu, Minghua Jin, Wei Huang, Zhiwei Sun*. Inhibition Effect of Cadmium Chloride on Human Hepatocellular Carcinoma Cells SMMC-7721. Chinese Journal of Public Health, 2006, 22(2): 194-195.

• Haiying Du, Xiaomei Liu, Ying Liu, Minghua Jin, Wei Huang, Zhiwei Sun*. The Anti-tumor Effect of Cadmium and the Mechanisms. Journal of Toxicology, 2005, 19(3) S: 234.