Education Experience:

• 1992/9-1997/7 Norman Bethune University of Medical Sciences, Bachelor in Preventive Medicine)

• 1997/9-2000/7 Norman Bethune University of Medical Sciences, Master in Toxicology

• 2000/9-2003/7 School of Public Health, Jilin University, PhD in Radiation medicine

Working Experience:

• 2000/7-2002/9 Teaching assistant, Department of Toxicology, School of Public Health, Jilin University

• 2002.9-2006.9 Lecturer, Department of Toxicology, School of Public Health, Jilin University  

• 2004.12-2005.12 Visit scholar Diabetes Transplant Unit, Prince of Wales Hospital, University of New South Wales, Austria

• 2006.9-2014/9 Associate professor, Department of Toxicology, School of Public Health, Jilin University

• 2014.9-present professor, Department of Toxicology, School of Public Health, Jilin University

Research Fields:

     Toxicological safety evaluation

• Environmental toxicology

• The repairing effect of mesenchymal stem cells on serious diseases and chemical poisoning

Research Projects:

• Grant of the Department of Science and Technology of Jilin Province（natural science funds of Jilin Province）, 20200201156JC, bone marrow mesenchymal stem cells repair testes injury caused by hexavalent chromium by regulating the mitophagy mediated by MAPK, 2020.1-2022.12, RMB 80, 000, PI

• Grant of the Department of Science and Technology of Jilin Province（natural science funds of Jilin Province）（Key scientific and technological research and development projects），20180201052YY, Toxicological safety evaluation of 3D printed orthopedic materials based on amorphous polyaryl ether ketone-sub-project of 3Dprinted orthopedic materials based on amorphous polyaryl ether ketone, 2018.1-2020.12, RMB 150, 000, PI

• Health and Family Planning Commission of Jilin Province, 2018J042, bone marrow mesenchymal stem cells repair liver injury caused by hexavalent chromium, 2019.1-2020.12, RMB 50, 000, PI

• Grant of the Department of Science and Technology of Jilin Province（natural science funds of Jilin Province）, 20160101230JC, the mechanism of mitophagy mediated by PINK1/Parkin pathway in bone marrow mesenchymal stem cells repairing testes injury caused by cadmium, 2016.1-2018.12, RMB 10000, PI

• Science & Technology Program during the Twelfth Five-year Plan Period of the Education Department of Jilin Province, [2015]533, the mechanism of reprogramming cell metabolism in bone marrow mesenchymal stem cells repairing cadmium-induced testicular injury in rats, 2015.1- 2016.12, RMB 30, 000, PI

• Scientific Research Foundation of Health and Family Planning Commission of Jilin Province, 2014Z046, the repairing effect of bone marrow mesenchymal stem cells on kidney injury caused by cadmium, 2015.1-2017.12, RMB 50, 000, PI

• Toxicological safety evaluation of nanometer hydroxyapatite, 2014649, Sichuan Aorui Medical Apparatus Co. Ltd，2014.7-2017.7，RMB 300, 000，PI

• Grant of the Department of Science and Technology of Jilin Province (International science and technology cooperation projects)，20130413023GH, bone marrow mesenchymal stem cells repair testes injury caused by hexavalent chromium, 2013.1-2015.12, RMB 700, 000，PI 

Publications:

• Zhao Y, Yan J, Li AP, Zhang ZL, Li ZR, Guo KJ, Zhao KC, Ruan Q, Guo L. Bone marrow mesenchymal stem cells could reduce the toxic effects of hexavalent chromium on the liver by decreasing endoplasmic reticulum stress-mediated apoptosis via SIRT1/HIF-1α signaling pathway in rats. Toxicol Lett, 2019, 310:31-38. (corresponding author)

• Yin F, Yan J, Zhao Y, Guo KJ, Zhang ZL, Li AP, Meng CY, Guo L. Bone marrow mesenchymal stem cells repair Cr (VI)-injured kidney by regulating mitochondria- mediated apoptosis and mitophagy mediated via the MAPK signaling pathway. Ecotoxicol Environ Saf, 2019, 176: 234-241. (corresponding author)

• Wang YJ, Yan J, Zou XL, Guo KJ, Zhao Y, Meng CY, Yin F, Guo L. Bone marrow mesenchymal stem cells repair cadmium-induced rat testis injury by inhibiting mitochondrial apoptosis. Chem Biol Interact, 2017, 271: 39-47. (corresponding author)

• Wang YJ, Yan J, Yin F, Li L, Qin YG, Meng CY, Lu RF, Guo L. Role of autophagy in cadmium-induced testicular injury. Hum Exp Toxicol, 2017, 36(10): 1039-1048. (corresponding author)

• Zhang H, Su X, Guo L, Zhong L, Li W, Yue Z, Wang X, Mu Y, Li X, Li R, Wang Z. Silencing SATB1 Inhibits the Malignant Phenotype and Increases Sensitivity of Human Osteosarcoma U2OS Cells to Arsenic Trioxide. Int J Med Sci, 2014, 11(12):1262-1269. (corresponding author)

• Yin F, Meng C, Lu R, Li L, Zhang Y, Chen H, Qin Y, Guo L. Bone marrow mesenchymal stem cells repair spinal cord ischemia/reperfusion injury by promoting axonal growth and anti-autophagy. Neural Regen Res, 2014, 9(18): 1665-1671. (corresponding author)

• Yin F, Guo L, Meng CY, Liu YJ, Lu RF, Li P, Zhou YB. Transplantation of mesenchymal stem cells exerts anti-apoptotic effects in adult rats after spinal cord ischemia-reperfusion injury. Brain Res, 2014, 1561:1-10. (corresponding author)

• Guo L, Yin F, Meng HQ, Ling L, Hu-He TN, Li P, Zhang CX, Yu S, Duan DS, Fan HX. Differentiation of mesenchymal stem cells into dopaminergic neuron-like cells in vitro. Biomed Environ Sci, 2005, 18(1): 36-42

• Zhang Xing , Yin Fei, Guo Li, Zhao Dongxu, Gong Gu, Gao Lei, Zhu Qingsan. Transplantation of neural stem cells, Schwann cells and olfactory ensheathing cells for spinal cord injury. NEURAL REGENERATION RESEARCH, 2012, (35): 2818-2825 2012 Dec

Awards:

• Zinc promotes the repairing effect of bone marrow mesenchymal stem cells on spinal cord ischemia-reperfusion injury, Public Health Science and Technology Award of Jilin Provincial (the First Zhongsheng Cup 2013-2014), the second award, 2014

Patent:

• A method for isolation and culture of rat spermatogonial stem cells without feeding layer, , invention, patent number: ZL 2018 1 1555089.2 application: 2018.12.18, authorization: 2019.10.25