Name: Jinyu Liu
Degree: MD & PhD
Professional qualification: Professor
Department：Toxicology
E-mail: jy_liu@jlu.edu.cn
Education Experience
1983/9-1988/7 N Bethune University of Medical Sciences, Bachelor in Medicine
1988/9-1991/7 School of Preventive Medicine N Bethune University of Medical Sciences Master in Toxicology
1995/9-1999/5 Institute of Regenerative Medicine N Bethune University of Medical Sciences PhD in Biochemistry
Working Experience
1991/8-1995/8 Environmental protection engineer Songliao Water Resources Protection Bureau, Changchun, China
1999/6-2004/5 Postdoctoral associate Department of Dermatology Zurich University Hospital, Switzerland
2004/6-2008/12 Research assistant professor Department of Chemical and Biological Engineering State University of New York at Buffalo, USA
2009-2015 Professor and vice director Department of Pathobiology, Key Lab of Ministry of Education College of Basic Medicine Jilin University, Changchun, China
2015/5-2017/6 Director and Assistant Dean of Toxicology Teaching and Research Office, School of Public Health, Jilin University
Research direction: stem cell biology and regenerative medicine, biopharmaceutics and health toxicology
2017/7 - now Deputy Dean, School of Public Health, Jilin University
Research direction: stem cell biology and regenerative medicine, tumor pathology and biology Biopharmacy and Health Toxicology
Research Fields
1. Stem cell biology and regenerative medicine
Mass production of clinical grade stem cells derived from human hair follicle, human Wharton’s jelly and induced pluripotent stem cells and use of these cells as cell sources: 1) To repair and regenerate damaged organs; 2) To construct functional artificial organs to replace damaged or lost organs; 3) To overexpress therapeutic gene for treatment of metabolic disorder, such as diabetic mellitus and aging.
2. Biopharmaceutical
Production of recombinant protein for correction of metabolic disorders, anti-aging and medical cosmetic using modern molecular biology and biopharmaceutical technology.
3. Toxicology
Toxicity of methylmercury
Research Projects
1. "PBX1 inhibits the accumulation of endogenous reactive oxygen species and promotes hair regeneration through the SIRT1-PARP1 axis". General program of National Natural Science Foundation of China (82273673). person in charge. Direct funds: 520000 yuan. Start and end date: 2023/01 - 2026/12
2. "PBX1 inhibits oxidative damage of HF-MSC induced by H2O2 and its mechanism". General program of the National Natural Science Foundation of China (82073581). person in charge. Direct funds: 560000 yuan. Start and end date: 2021/01-2024/12
3. "Research and development of key technologies and products for the preparation of non injectable recombinant human insulin". Jilin Provincial Department of Science and Technology (20190304044YY). person in charge. 500000 yuan. Starting and ending time: 2019/01-2021/12
4. "Key technologies and products for preparation of recombinant human insulin fusion protein administered through oral mucosa". Jilin Industrial Technology Research and Development Project (2018C049-2). person in charge. 250000 yuan. Starting and ending time: January 2018/December 2019
5. "Mesenchymal stem cell preparation process and its quality control standard". Jilin Provincial School Co construction Plan Special Project (SXGJQY2017-12). person in charge. 1 million yuan. Start and end date: September 2017 - August 2020
6. "Study on the effect of AIF mediated Caspase independent apoptosis signal pathway on hair follicle cycle and its mechanism". General program of National Natural Science Foundation of China (81573067). person in charge. Direct funds: 550000 yuan. Start and end date: January 2016/December 2019
7. "A method for massive expansion of hair follicle stem cells in vitro". Xiamen Zhengmeinong Biotechnology Co., Ltd. (3R115G963426). person in charge. 360,000 yuan
8. "Experimental study on the construction and animal transplantation of tissue engineered arterial vessels based on human adult hair follicle stem cells". Key Program of National Natural Science Foundation of China (30930026) (3A209N173426). person in charge. 1.66 million yuan. Start and end date: 2010/01-2013/12
9. "The influence of physical properties of materials on cell behavior and the mechanism of their translation into intracellular signals". 973 Plan "Molecular Mechanism and Design Principle of Tissue Induction of Biomedical Materials" (2011CB606201). First participant. 1.86 million yuan. Start and end date: 2011/1-2015/12
10. "Preparation and preclinical study of new genetically modified engineering drugs". Key project of Jilin Provincial Science and Technology Department (20,100,947) (3D510S623,426). person in charge. 120,000 yuan. Start and end date: January 2013/December 2011
11. "Research on clinical application of autologous tissue engineered skin". Shanghai Xuanjie Biotechnology Co., Ltd. (3R1,114,003,426). person in charge. 800000 yuan. Start and end date: January 2011 December 2013
12. "Hair follicle stem cell transplantation for ischemic myocardial necrosis". The Ministry of Education launched the project for returned overseas students (3D511Z853426). person in charge. 40000 yuan. Start and end date: 2010/01-2013/12
13. "MicroRNA18b in TGF- β Study on the molecular mechanism of inducing hair follicle mesenchymal stem cells to differentiate into vascular smooth muscle cells ". Doctoral Program Fund (Doctoral Guidance) (20130061110077) (3M213BR63426). person in charge. 120,000 yuan. Start and end date: 2014/01-2016/12
14. "Construction of tissue engineered blood vessels based on iPS cells". Cross project of Jilin University Medical Department (2013101007) (47011000035). person in charge. 100000 yuan. Start and end date: 2014/01-2016/12
15. "Repair of ischemic myocardial disease with autologous hair follicle mesenchymal stem cells transplantation". Special Medical Program of Jilin Provincial Science and Technology Department (200905180). person in charge. 30000 yuan. Start and end date: January 2009 to December 2011
16. "Experimental study on construction and animal transplantation of hair follicle derived tissue engineered bone". Fund of the Director of the Fund Committee (3D611Z863426). person in charge. 10000 yuan. Start and end date: 2011/1-2011/12
Selected Publications
1.Yuan Wang, Yutong Sui, Ye Niu, Dan Liu, Qi Xu, Feilin Liu, Kuiyang Zuo, Mingsheng Liu, Wei Sun, Ziyu Wang, Zinan Liu, Fei Zou, Jiahong Shi, Xiaomei Liu, and Jinyu Li u. PBX1-SIRT1 positive feedback loop attenuates ROS-mediated HF- MSCs senescence and apoptosis. Stem Cell Rev Rep. 2022 Aug 12. doi: 10.1007/s12015-022-10425-w. Online ahead of print (IF 6.692)
2.Mingsheng Liu, Xiaomei Liu,Yuan Wang, Yutong Sui, Feilin Liu, Zinan Liu, Fei Zou, Kuiyang Zuo, Ziyu Wang, Wei Sun, Qi Xu, Dan Liu, and Jinyu Liu*.Intrinsic ROS drive hair follicle cycle progression by modulating DNA damage and repair, and subsequently, hair follicle apoptosis and macrophage polarization. Oxid Med Cell Longev. 2022 Jul 14. doi: 10.1155/2022/8279269. eCollection 2022 (IF 7.310)
3.Yuan Wang, Yutong Sui, Aobo Lian, Xing Han, Feilin Liu， Kuiyang Zuo , Mingsheng Liu, Wei Sun, Ziyu Wang, Zinan Liu, Fei Zou, Rifeng Lu, Minghua Jin, Haiying Du, Kan Xu, Xiaomei Liu, Jinyu Liu*. PBX1 Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence and Apoptosis by Alleviating Reactive Oxygen Species-Mediated DNA Damage Instead of Enhancing DNA Damage Repair. Front Cell Dev Biol. 2021 Nov 15;9:739868. doi: 10.3389/fcell.2021.739868. eCollection 2021. (IF6.684)
4.Ruirui Fan, Xiaomei Liu, Feilin Liu, Zinan Liu, Xing Han, Aobo Lian, Yuan Wang,Kuiyang Zuo, Mingsheng Liu, Fei Zou, Minghua Jin, and JinYu Liu*. Melanocytes derived from mouse hair follicles: a novel study model to assess pigmentation disorders. Pathol Res Pract. 2020 Nov;216(11):153224 (IF2.05）
5.Bo Wang, Feilin Liu, Zinan Liu, Xing Han, Aobo Lian, Yuying Zhang, Kuiyang Zuo, Yuan Wang, Mingsheng Liu, Fei Zou, Yixu Jiang, Minghua Jin, Xiaomei Liu, and Jinyu Liu* Internalization of the TAT-PBX1 fusion protein significantly enhances the proliferation of human hair follicle-derived mesenchymal stem cells and delays their senescence. Biotechnology Letters 2020 Oct;42(10):1877-1885 (IF1.977)
6.Bo Wang, Xiaomei Liu, Zinan Liu, Yuan Wang, Xing Han, Aobo Lian,, Minghua Jin, and Jinyu Liu* Human hair follicle-derived mesenchymal stem cells: isolation, expansion and differentiation. World Journal of Stem Cells. 2020; Jun 26,12(6): 462-470 (IF3.231)
7.Guifang Zhao, Feilin Liu, Zinan Liu, Kuiyang Zuo, Bo Wang,Yuying Zhang, Xing Han, Aobo Lian,Yuan Wang, Mingsheng Liu, Fei Zou, Xiaomei Liu, Minghua, Jin and Jin Yu Liu* MSC-Derived Exosomes Attenuate Cell Death through Suppressing AIF Nucleus Translocation and Enhance Cutaneous Wound Healing. Stem Cell Research & Therapy. 2020 May 11;11(1):174 (IF5.116)
8.Feilin Liu, Jiahong Shi,Yingyao Zhang, Aobo Lian, Xing Han, Kuiyang Zuo, Mingsheng Liu, Tong Zheng, Fei Zou, Xiaomei Liu, Ming-Hua Jin, Ying Mu, Gang Li, Guanfang Su*,and Jin Yu Liu* NANOG Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence by Upregulating PBX1 and Activating AKT Signaling. Oxidative Medicine and Cellular Longevity. 2019 Dec 4 (IF 5.076）
9.Yixu Jiang, Feilin Liu, Fei Zou, Yingyao Zhang, Bo Wang, Yuying Zhang, Aobo Lian, Xing Han, Zinan Liu, Xiaomei Liu, Minghua Jin, Dianliang Wang, Gang Li, and Jinyu Liu*. PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis. Stem Cell Research & Therapy, 2019 Aug 23;10(1):268 (IF5.116)
10.SHI Jia Hong, ZUO Kui Yang, ZHANG Ying Yao, WANG Bo, HAN Xing, LIAN Ao Bo, and LIU Jin Yu*. NANOG Alleviates the Damage of Human Hair Follicle Mesenchymal Stem Cells Caused by H2O2 through Activation of AKT Pathway. Biomed Environ Sci, 2019; 32(4): 272-280(IF2.656)
11.Fei Zou, Zhe Wang, Lei Wang, Yuying Zhang, Mingsheng Liu, and Jinyu Liu*. Hot Spots and Trends of Research on Human Umbilical Cord Mesenchymal Stem Cells: A Bibliometric Analysis. Journal of Biomaterials and Tissue Engineering. 2019, 9, 1–8 (IF0.5116)
12.Ma Y, Li M, Liu J, Pang C, Zhang J, Li Y, Fu X. Location, Isolation, and Identification of Mesenchymal Stem Cells from Adult Human Sweat Glands. Stem Cells International 2018, Article ID 2090276, 12 pages.
13.Tingting Bai, Feilin Liu, Fei Zou, Guifang Zhao, Yixu Jiang, Li Liu, Jiahong Shi, Deshun Hao, Qi Zhang, Tong Zheng, Yingyao Zhang, Mingsheng Liu, Shilun Li, Liangchen Qi, and Jin Yu Liu*Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated with Upregulation of Cyclin D1 and Downregulation of p16. Stem Cells Dev. 2017 Jan 15;26(2):113-122(IF3.39)
14.Dan Zhou, Hongjing Cheng, Jinyu Liu, Lei Zhang. Establishment of human hair follicle mesenchymal stem cells with overexpressed human hepatocyte growth factor. Iran J Basic Med Sci. 2017 Jun;20(6):662-675
15.Li, Pengdong; Liu, Feilin; Wu, Chunling; Jiang, Wenyue; Zhao, Guifang; Liu, Li; Bai, Tingting; Wang, Li; Lan, Shaowei; Guo, Lili; Li, Yulin; Jin Yu Liu* Feasibility of human hair follicle-derived mesenchymal stem cells/CultiSpher®-G constructs in regenerative medicine. Cell Tissue Res. 2015 Oct;362(1):69-86
16.G Zhao, F Liu, S Lan, P Li, Li Wang, J Kou, X Qi, R Fan, D Hao, C Wu, T Bai, Y Li and JY Liu* Large-scale expansion of Wharton's jelly-derived mesenchymal stem cells on gelatin microbeads, with retention of self-renewal and multipotency characteristics and the capacity for enhancing skin wound healing. Stem Cell Res Ther. 2015 Mar 19;6(38):1-16
17.S Lan, F Liu, G Zhao, T Zhou, C Wu, J Kou, R Fan, X Qi, Y Jiang, T Bai, P Li, L Liu, D Hao, L Zhang, Y Li, JY Liu* Cyclosporine A increases hair follicle growth by suppressing AIF nuclear translocation: A new mechanism. Fundam Clin Pharmacol. 2015 Apr;29(2):191-203
18.C Wu, F Liu, P Li, G Zhao, S Lan, W Jiang, X Meng, L Tian, G Li, Y Li*, Jin Yu Liu*. Engineered Hair Follicle Mesenchymal Stem Cells Overexpressing Controlled-Release Insulin Reverse Hyperglycemia in Mice with Type l Diabetes. Cell Transplant. 2015 ;24(5):891-907
19.Zhang Y, Chen X, Liu J, Zhang Y . The protective effects and underlying mechanism of an anti-oligomeric Aβ42 single-chain variable fragment antibody. Neuropharmacology. 2015 Dec; 99:387-95
20.M Li, JinYu Liu, S Wang H, Xu, L Cui, S Lv, J Xu, S Liu, G Chi, Y Li， Multipotent neural crest stem cell-like cells from rat vibrissa dermal papilla induce neuronal differentiation of PC12 cells. Biomed Res Int. 2014; 2014:186239
21.Yunhe Gao, Feilin Liu, Lihong Zhang, Xuejin Su, Jin Yu Liu*, and Yulin Li* Acellular Blood Vessels Combined Human Hair Follicle Mesenchymal Stem Cells for Engineering of Functional Arterial Grafts. Ann Biomed Eng. 2014 Oct;42(10):2177-89
22.Yunhe Gao, Meiying Li, Xueyan Zhang, Guangfan chi, Jin Yu Liu* and Yulin Li*. Isolation, culture and phenotypic characterization of human sweat gland epithelial cells. Int J Mol Med. 2014 Oct;34(4):997-1003
23.Xuejuan Liu, Lei Song, Jinyu Liu, Shichao Wang, Xiaohua Tan, Xiaoguang Bai,Tingting Bai, Yimei Wang, Meiying Li, Yaolin Song, Yulin Li*, MiR-18b inhibites TGF-β1-induced differentiation of hair follicle stem cells into smooth muscle cells by targeting SMAD2. BBRC,2013 Aug. 30;438(3):551-6
24.Yimei Wang, Jinyu Liu, Xiaohua Tan, Gaofeng Li, Xuejuan Liu, Lihong Zhang, Yulin Li*, Induced pluripotent stem cells from human human hair follicle mesenchymal stem cells. Stem Cell Review and Reports. 2013, 9(4):451–460
25.Xueyan Zhang, Yimei Wang, Yunhe Gao, Xuejuan Liu, Tingting Bai, Meiying Li, Guangfan Chi, Hui Xu, Feilin Liu, Jinyu Liu, Yulin Li*. Maintenance of high proliferation and multipotent potential of human hair follicle-derived mesenchymal stem cells by growth factors. Int J Mol Med. 2013 Apr; 31(4): 913-21
26.Mohammed Nader Shalaby, Jin Yu Liu*, Mona Mahmoud Kassem, Mohammed Saad. Circulating Hematopoietic Stem Cell and Some Physiological Parameters in Different Training Programs. Life Sci J 2012; 9(1):965-971
27.Mohamed Nader Shalaby, Jin Yu Liu*, Mohamed Saad and Hossam Elaraby. Impacts of Different Exercise Intensities on Hematopoietic Stem Cells and Certain Physiological Parameters on Handball Players and Non-Athletes. Life Sci J 2012;9(3):2100-2105
28.Mohammed Nader Shalaby, Jin Yu Liu, Hussein Heshmat,Nader M. Shalaby, Mohammed Salah Zaeid, Ahmed Ibrahim Shalgham, Maged Elazazy, Samy Akar, Hossam Elaraby, Mohammed AbdelrazikTaha and Wael Elfiel. The Effect of Aerobic and Anaerobic Exercise Bouts on CD34+ Stem Cells and Some Physiological Parameters. Life Sci J 2012; 9(2): 1037-1043
29.Hao Fan Peng，Jin Yu Liu, Stelios T. Andreadis and Daniel D. Swartz. Hair Follicle-Derived Smooth Muscle Cells and Small Intestinal Submucosa for Engineering Mechanically Robust and Vasoreactive Vascular Media. Tissue Eng Part A. 2011 Apr;17(7-8):981-90
30.Jin Yu Liu, Hao Fan Peng，JunTian and Stelios T. Andreadis. Derivation of Functional Smooth Muscle Cells from Multipotent Human Hair Follicle Mesenchymal Stem Cells. Tissue Eng Part A. 2010 Aug;16(8) :2553-64
31.Juhee Han, Jin Yu Liu,Daniel D. Swartz and Stelios T. Andreadis. Molecular and functional effects of organismal ageing on smooth muscle cells derived from bone marrow mesenchymal stem cells. Cardiovasc Res. 2010 Jul 1;87(1):147-55
32.Jin Yu Liu, Hao Fan Peng and Stelios T. Andreadis. Contractile smooth muscle cells derived from hair follicle stem cells. Cardiovasc Res. 2008 Jul 1; 79(1):24-33
(The abstract of the paper was republished by "New England Journal of Medicine")
33.Jin Yu Liu, Daniel D. Swartz, Hao Fan Peng, Silviya F. Gugino, James A. Russell, and Stelios T. Andreadis. Functional tissue-engineered blood vessels from bone marrow progenitor cells. Cardiovasc Res. 2007 Aug 1;75(3):618-28
34.Yao Lan, Jin Yu Liu, Stelios Andreadis. Composite Fibrin Scaffolds Increase Mechanical Strength and Preserve Contractility of Tissue Engineered Blood Vessels. Pharmaceutical Research, 2008 May;25(5):1212-21
35.Jin Yu Liu, Jurg Hafner, Galya Dragieva, Gunter Burg. A novel bioreactor microcarrier cell culture system for high yields of proliferating autologous human keratinocytes. Cell Transplantation. 2006;15(5):435-43
36.Jin Yu Liu, Jurg Hafner, Galya Dragieva, Gunter Burg. High yields of autologous living dermal equivalents using porcine gelatin microbeads as microcarriers for autologous fibroblasts. Cell Transplantation. 2006;15(5):445-51
37.Jin Yu Liu, Gunter Burg. An improved organ culture for regeneration of pure autologous keratinocytes from small split-thickness skin specimens. Dermatology. 2005;210(1):45-8.
38.Jin Yu Liu, Jurg Hafner, Galya Dragieva, Burkhardt Seifert, Gunter Burg. Autologous cultured Keratinocytes on porcine gelatin microbeads effectively heal chronic venous leg ulcers. Wound Repair Regen. 2004 Mar-Apr;12(2):148-56
39.Jin Yu Liu, Jurg Hafner, Galya Dragieva, Gunter Burg. Bioreactor microcarrier cell culture system (Bio-MCCS) for large-scale production of autologous melanocytes. Cell Transplantation. 2004;13(7-8):809-16
