Education Experience

Working Experience

• July 2017–Now, Associate Professor, Department of Health Toxicology, School of Public Health, Jilin University, China.

Research Fields

• Analysis and toxicological study of emerging water disinfection byproducts

• Pharmacodynamics and preclinical safety evaluation of novel drugs

• Detection technology of environmental contaminants

Research Projects

• Adverse effects of water disinfection byproducts, Overseas Doctoral A-level Talent Program of Jilin University, China, 2017/07-2020/07, 350 000 RMB. (PI)

• Potential mechanism of halobenzoquinone-induced neurodevelopmental toxicity in SH-SY5Y cells, Bethune Research Project of Jilin University (2018B34), 2019/01 ‒2020/12, 50 000 RMB. (PI)

• Outstanding Young Teachers Program of Jilin university, 2019/01-2021/12, 180 000 RMB. (PI)

• Natural Sciences and Engineering Research Council of Canada Strategic, Identification of new water disinfection byproducts of health importance, 2015-2018, $453,500. (PI, Xing-Fang Li)

• Natural Sciences and Engineering Research Council of Canada Strategic, Novel tools for characterization of new drinking water disinfection byproducts and health effects, 2012-2015, $542,000. (PI, Xing-Fang Li)

Publications

• Na Li^#, Jinhua Li^#, Qingqing Zhang, Shenshen Gao, Xu Quan, Ping Liu, Chundi Xu. Effects of endocrine disrupting chemicals in host health: Three-way interactions between environmental exposure, host phenotypic responses, and gut microbiota. Environmental Pollution, 2021, 271: 116387. (co-first author)  

• Yan Zheng, Hongmei Gan, Yao Zhao, Wanling Li, Yuchen Wu, Xuechun Yan, Yifan Wang, Jinhua Li*, Juan Li*, and Xin-Long Wang*. Self-Assembly and Antitumor Activity of a Polyoxovanadate‐Based Coordination Nanocage. Chem. Eur. J. 2019, 25(67), 15326 – 15332. (co-corresponding author)

• Bo Pang#, Yan Zheng#, Juan Wang, Yushen Liu, Xiuling Song, Jinhua Li, Shuo Yao, Kaiyue Fu, Kun Xu*, Chao Zhao* and Juan Li*. Colorimetric detection of Staphylococcus aureus using gold nanorods labeled with yolk immunoglobulin and urease, magnetic beads and a phenolphthalein impregnated test paper. Microchimica Acta, 2019, 186: 611.

• Xinxin Li, Xuejing Li, Yuanyuan Guo, Yushen Liu, Shujuan Mei, Xiuling Song, Jinhua Li, Alvin G. Grugbaye, Juan Li and Kun Xu. Development and Assessment of a Paper-based Enzyme-linked Immunosorbent Assay for the Colorimetric Diagnosis of Human Brucellosis. Analytical Letters, 2019, 52(10): 1614-1628.  

• Jinhua Li*, Birget Moe, Yanming Liu, and Xing-Fang Li*. Halobenzoquinone-induced alteration of gene expression associated with oxidative stress signaling pathways. Environmental Science and Technology, 2018, 52(11): 6576-6584. (co-corresponding author)

• Jinhua Li, Madlen Bauer, Birget Moe, Elaine M. Leslie, and Xing-Fang Li. Multidrug resistance protein 4 (MRP4/ABCC4) protects cells from the toxic effects of halobenzoquinones. Chem. Res. Toxicol., 2017, 30(10):1815-1822.  

• Katherine Z. Fu^#, Jinhua Li^#, Sai Vemula, Birget Moe, and Xing-Fang Li. Effects of halobenzoquinone and haloacetic acid water disinfection byproducts on human neural stem cells. J. Environ. Sci., 2017, 58, 239-249. (co-first author)

• Jinhua Li, Birget Moe, Sai Vemula, Wei Wang, and Xing-Fang Li. Emerging disinfection by-products, halobenzoquinones: effects of isomeric structure and halogen substitution on cytotoxicity, formation of reactive oxygen species, and genotoxicity. Environmental Science and Technology, 2016, 50 (13), 6744–6752.

• Jinhua Li, Katherine Fu, Sai Vemula, Chris X. Le, and Xing-Fang Li. Studying developmental neurotoxic effects of bisphenol A (BPA) using embryonic stem cells. Journal of Environmental Sciences, 2015, 36, 173-177.

• Jinhua Li, Wei Wang, Birget Moe, Hailin Wang, and Xing-Fang Li. Chemical and toxicological characterization of halobenzoquinones, an emerging class of disinfection byproducts. Chemical Research in Toxicology, 2015, 28(3): 306-318. (Editorial Advisory Board Members’ Favorite CRT Articles)

• Jinhua Li, Wei Wang, Hongquan Zhang, X. Chris Le, and Xing-Fang Li. Glutathione mediated detoxification of halobenzoquinone drinking water disinfection byproducts in T24 cells. Toxicological Sciences, 2014, 141(2): 335-343.

• Haiying Du^#, Jinhua Li^#, Birget Moe, Claire F. McGuigan and Xing-Fang Li. A real-time cell-electronic sensing method for comparative analysis of toxicity of water contaminants. Analytical Methods, 2014, 6, 2053-2058. (co-first author)

• Haiying Du^#, Jinhua Li^#, Birget Moe, Claire F. McGuigan, Shengwen Shen, and Xing-Fang Li. Cytotoxicity and oxidative damage induced by halobenzoquinones to T24 bladder cancer cells. Environmental Science and Technology, 2013, 47(6):2823-30. (co-first author)

• Xiaowen Yan, Jinhua Li, Qingqing Liu, Hanyong Peng, Aleksandra Popowich, Zhixin Wang, Xing-Fang Li, and X. Chris Le. p-Azidophenylarsenoxide: An Arsenical "Bait" for the In Situ Capture and Identification of Cellular Arsenic-Binding Proteins. Angewandte Chemie International Edition, 2016, 55(45), 14051-14056.

• Wei Wang, Yichao Qian, Jinhua Li, Naif Aljuhani, Arno G. Siraki, X. Chris Le, and Xing-Fang Li. Characterization of Mechanisms of Glutathione Conjugation with Halobenzoquinones in Solution and HepG2 Cells. Environmental Science and Technology, 2018, 52(5): 2898-2908.

• Birget Moe, Chungang Yuan, Jinhua Li, Haiying Du, Stephan Gabos, X. Chris Le, and Xing-Fang Li. Real-Time Cell-Electronic Sensing of Coal Fly Ash Particulate Matter for Toxicity-Based Air Quality Monitoring. Chemical Research in Toxicology, 2016, 29 (6), 972–980. (American Chemistry Society (ACS) Editors' Choice)

• Wei Wang, Birget Moe, Jinhua Li, Yichao Qian, Qi Zheng, and Xing-fang Li. Analytical characterization, occurrence, transformation, and removal of the emerging disinfection byproducts halobenzoquinones in water. Trends in Analytical Chemistry, 2016, 85: 97-110.

• Wei Wang, Yichao Qian, Jinhua Li, Birget Moe, Rongfu Huang, Hongquan Zhang, Steve E. Hrudey, and Xing-Fang Li. Analytical and toxicity characterization of halo-hydroxyl-benzoquinones as stable haloquinone disinfection byproducts in treated water. Analytical Chemistry, 2014, 86, 4982-4988.

• Hanyong Peng, Bin Hu, Qingqing Liu, Jinhua Li, Xing-Fang Li, Hongquan Zhang, and X. Chris Le. Methylated phenylarsenical metabolites discovered in chicken liver. Angew. Chem. Int. Ed., 2017, 56, 6773.

• Juan Wang, Xiaofeng Qu, Yanfei Qi, Jinhua Li, Xiuling Song, Li Li, Dehui Yin, Kun Xu, and Juan Li. Pharmacokinetics of Anti-HBV Polyoxometalate in Rats. PLoS One, 2014, 9(6): e98292.

• Jiahui Wu, Hongfang Wang, Zhicheng Wang, Kai Xu, Yali Qi, Jinhua Li, Shouliang Gong Yang Liu, and Ya Liu. Conditionally replicating adenovirus combined with gene-targeted radiotherapy induces apoptosis via TRAIL death receptors in MDA-MB-231 cells. Molecular Medicine Reports, 2013, 8, 299-305.

• Yan-fei Qi, Hong Zhang, Juan Wang, Yanfang Jiang, Jinhua Li, Ye Yuan, Shiyao Zhang, Kun Xu, Yangguang Li, Juan Li*, Junqi Niu, Enbo Wang. In vitro anti-hepatitis B and SARS virus activities of a titanium-substituted-heteropolytungstate. Antiviral Research, 2012, 93(1):118-25.

Professional Services

1. Professional Organizations

• Committee member, Member of Environmental Stress and Health Damage Division, China Mutagenesis Society

• Committee member, Youth Committee of Chinese Toxicology Society, 2018-present

• Committee member, Youth Committee of Health Toxicology Division, Association of Chinese Preventive Medicine, 2018-present

2.   Review Manuscripts for the Following International Journals

• Chemosphere

• Environmental Sciences and Technology

• Journal of Environmental Sciences

• Environmental Pollution