Education Experience

• 2011.09-2014.06   Doctorate of Hygienic Toxicology, Jilin University,

• 2009.09-2011.06   Master of Environmental Health, Jilin University

• 2004.09-2009.06  Bachelor of Preventive Medicine, Jilin University

Working Experience

• 2019.9-present  Associate Professor, School of Public Health, Jilin University

• 2015.6-2019.9 Lecturer, School of Public Health, Jilin University

• 2014.09-Present  Postdoc, Department of Respiratory, No. 1 Hospital of Jilin University

Research Fields

• Health effects of environmental hazards and underlying mechanisms

Research Projects

• The mechanisms underlying ambient PM2.5 regulating lipid level through Notch signaling pathway and their role in the development and progression of coronary heart disease. National Natural Science Foundation for young experts project (81803190), 2019.01- 2021.12, 210,000 Yuan, Principal Investigator.

• Dual regulation mechanisms of Notch signaling pathway in the lipid metabolism disorder caused by DEHP. The Department of Education of Jilin Province (JJKH20201118KJ), 2020.01-2021.12，25, 000 Yuan, Principal Investigator.

• Role and mechanisms of CD40/CD40L in the effects of PM2.5 on the atherosclerosis. The Department of Health of Jilin Province for young scientist project (2019Q010), 2020.01-2022.12, 20,000 Yuan, Principal Investigator.

• Regulating mechanism of ANRIL in the bronchi inflammation caused by PM2.5. 2017 Science and Technology Key project of the thirteenth Five-Year Plan, the Department of Education (JJKH20170874KJ), 2017.01-2018.12, 50,000 Yuan, Principal Investigator.

• Role of Muc5b in the bronchi inflammation caused by PM 2.5 and relevant mechanisms. The Department of Science and Technology of Jilin Province for Young Scientist Project (20160520159JH), 2016/01- 2018/12, 60000 Yuan, Principal Investigator.

• Effects of Meteorological factors and PM 2.5 on respiratory diseases and inflammation related mechanisms. Key laboratory of Meterology and Health open project of Shanghai (QXJK201506), 2015/12- 2017/1, 30000 Yuan, Principal Investigator.

• Mechanisms of Notch signaling pathway in the lipid metabolism disorder caused by DEHP. Norman Bethune Support Project of Jilin University.  2019.01-2020.12, 50000 Yuan, Principal Investigator.

• Effects of PM 2.5 on chronic respiratory diseases and relevant mechanisms. Scientific Research Basic Training Project of Jilin University, 2016/01-2016/12, 50000Yuan, Principal Investigator.

• Role of CD40/CD40L in the damage of vascular endothelial cells caused by PM 2.5 and relevant mechanisms. Yong Faculty and Student Connecting Project，2019.06-2021.06, 20000 Yuan, Principal Investigator.

Publications

• Yang L^#, Zhang Y^#, Qi W, Zhao T, Zhang L, Zhou L*, Ye L*.Adverse effects of PM2.5 on cardiovascular diseases. Rev Environ Health. 2021 Apr 1. doi: 10.1515/reveh- 2020-0155.

• Guo S^#, Zhang B^#, Qi W, Cao X, Xu Y, Zhang X, Li X, Zhou L*, Ye L*. Role of estrogen receptor alpha in MEHP-induced proliferation and invasion of SH-SY5Y cells. Toxicology. 2021 Feb 22;453:152734. doi: 10.1016/j.tox.2021.152734. Online ahead of print.

• Shi Y^#, Qi W^#, Xu Q, Wang Z, Cao X, Zhou L*, Ye L*. The role of epigenetics in the reproductive toxicity of environmental endocrine disruptors. Environ Mol Mutagen. 2021 Jan;62(1):78-88.

• Qi W, Xu Q, Xu Y, Wang Z, Yang L, Guo S, Shi Y, Zhao T, Zhou L*, Ye L*. Effect of Notch pathway on lipid accumulation induced by mono-2-ethylhexyl phthalate on 3T3-L1 cells. Ecotoxicol Environ Saf. 2021 Jan 15;208:111472.

• Liu Y, Zhou T, Sun L, Wang H*, Zhou L*. The effect of Notch signal pathway on PM2.5-induced Muc5ac in Beas-2B cells. Ecotoxicol Environ Saf. 2020 Oct 15;203:110956.

• Xu Q, Qi W, Zhang Y, Wang Q, Ding S, Han X, Zhao Y, Song X, Zhao T, Zhou L*, Ye L*. DNA methylation of JAK3/STAT5/PPARγ regulated the changes of lipid levels induced by di (2-ethylhexyl) phthalate and high-fat diet in adolescent rats. Environ Sci Pollut Res Int. 2020 Aug;27(24):30232-30242.

• Liu Y, Zhang B, Zhang T, Wang H, Peng L*, Zhou L*. Effect of NF-κB signal pathway on mucus secretion induced by atmospheric PM 2.5 in asthmatic rats. Ecotoxicol Environ Saf. 2020 Mar 1;190:110094.

• Han X^#, Gao Y^#, Qi W, Ding S, Zhang Y, Xu Q, Zhao Y, Song X, Zhao T, Zhou L*, Ye L*. Arch Environ Occup Health. 2020;75(6):365-370.

• Zhang Y, Wang S, Zhao T, Yang L, Guo S, Shi Y, Zhang X, Zhou L*, Ye L*. Mono-2-ethylhexyl phthalate (MEHP) promoted lipid accumulation via JAK2/STAT5 and aggravated oxidative stress in BRL-3A cells. Ecotoxicol Environ Saf. 2019 Nov 30;184:109611.

• Zhang T^#, Zheng Y^#, Gao Y, Zhao T, Guo S, Yang L, Shi Y, Zhou L*, Ye L*.Exposure to PM 2.5 affects blood lipid levels in asthmatic rats through notch signaling pathway. Lipids Health Dis. 2019 Aug 7;18(1):160.

• Zhou L, Chen H, Xu Q, Han X, Zhao Y, Song X, Zhao T, Ye L*. The effect of di-2-ethylhexyl phthalate on inflammation and lipid metabolic disorder in rats. Ecotoxicol Environ Saf, 2019, 170: 391-398.

• Zhou L ^#, Zheng D ^#, Song X, Zhu J, Qi W, Ding S, Zhang Y, Xu Q, Han X, Zhao Y, Zhao T, Guo S, Shi Y, Yang L, Ye L*. Alternated mRNA expression of the genes in chromosome 9p21 is associated with coronary heart disease and genetic variants in chromosome 9p21. Thromb Res. 2019 Jun;178:17-19.

• Zhou L, Liu Y, Chen X, Wang S, Liu H, Zhang T, Zhang Y, Xu Q, Han X, Zhao Y, Song X, Ye L*. Over-expression of nuclear factor-κB family genes and inflammatory molecules is related to chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis, 2018, 13: 2131-2138.

• Yuezhu Zhang, Shuyue Wang, Jian Zhu, Chunyan Li, Tianrong Zhang, Hongbo Liu, Qi Xu, Xiaofang Ye, Liting Zhou*, Lin Ye*, Effect of Atmospheric PM2.5 on Expression Levels of NF-κB Genes and Inflammatory Cytokines Regulated by NF-κB in Human Macrophage, Inflammation. 2018, 41(3): 784-794.

• Ru-xuan Zhang ^#, Na Li ^#, Jin Jin, Ting-ting Jiang, Yu-wei Wu, Li-ting Zhou*. Role of NF- κ B signaling pathway in airway inflammation of rats induced by atmospheric PM2.5. Asian Pacific Journal of Tropical Medicine, 2018, 11, Suppl S1:40.

• Di Sun^#, Liting Zhou^#, Shuyue Wang, Te Liu, Jian Zhu, Yiyang Jia, Jin Xu, Huaiji Chen, Qi Wang, Feng Xu, Yuezhu Zhang, Lin Ye*, Effect of Di-(2-ethylhexyl) phthalate on the hypothalamus-pituitary-thyroid axis in adolescent rat, Endocrine Journal, 2018, 65(3). 261-268.

• Jin Xu^#, Liting Zhou^#, Shuyue Wang, Jian Zhu, Te Liu, Yiyang Jia, Di Sun, Huaiji Chen, Qi Wang, Feng Xu, Yuezhu Zhang, Hongbo Liu, Tianrong Zhang, Lin Ye*, Di-(2-ethylhexyl)-phthalate induces glucose metabolic disorder in adolescent rats, Environ Sci Pollut Res Int, 2018, 25(4): 3596-3607.

• Liting Zhou，Lin Xie，Dongchun Zheng，Na Li，Jian Zhu，Shuyue Wang，Bo Li，Lin Ye*，Genetic Variants of CD40 Gene Are Associated with Coronary Artery Disease and Blood Lipid Levels，BioMed Research International，2016.1693619.

• Liting Zhou, Dongchun Zheng, Shuyue Wang, Jian Zhu, Yiyang Jia, Di Sun, Jin Xu, Qi Wang, Huaiji Chen, Feng Xu, Bo Li*, Lin Ye*. Genetic association of Toll-like receptor 4 gene and coronary artery disease in a Chinese Han population, SpringerPlus, 2016, 5:1533.