Education Experience

• 2003.06-2006.06 Doctorate of Radiation Medicine, Jilin University

• 1993.09-1999.06 Master of Environmental Health, Norman Bethune University of Medical Sciences.

• 1978.09-1983.07 Bachelor of Medicine, Norman Bethune University of Medical Sciences.

Working Experience

• 2005.03-present, Professor and Director of Department of Preventive Medicine, School of Public Health, Jilin University

• 2000.06-2005.03  Professor and Director of Division of Environmental Health, School of Public Health, Jilin University

• 1983.07-2000.06  Lecturer, Associate Professor, School of Preventive Medicine, Norman Bethune University of Medical Sciences

Research Fields

• Health effects of environmental hazards and relevant mechanisms

• Environmental Genome

Research Projects

• National Natural Science Foundation of China project: Study on the role of estrogen receptor network in thyroid toxicity of DEHP and its mechanism based on gene chip

• National Natural Science Foundation of China project: JAK-STAT signaling pathway mediates lipid metabolism disorder induced by DEHP

• Project of science and technology department of jilin province: preparation of apolipoprotein B100 antibody and its application in diagnosis and treatment of coronary heart disease

• Project of Science and Technology Department of Jilin Province: Effects of atmospheric PM2.5 on COPD acute exacerbation and its inflammatory regulation mechanism

• Lateral topic: Study on the role and mechanism of plasticizer DEHP in promoting ovarian granulosa cell apoptosis through COX-2/PGE2 in infertility

• The Ministry of Environmental Protection and the National Health and Family Planning Commission "Special Investigation Project on Environment and Health in Key Areas of China" : Formulated the implementation plan of special investigation on environment and health in key areas of China

• The relationship between PM2.5 and its main components and acute exacerbation of COPD and its effect on gene expression of NF-κB family

• The relationship between meteorological factors and cardiovascular and cerebrovascular diseases and respiratory diseases and their mechanisms

• The relationship between genetic variation on chromosome 9p21.3 and expression of its adjacent genes and coronary heart disease

• Changchun Municipal Health Bureau - World Health Organization Project: Changchun Municipal Action Plan on Climate Change and Health Protection

• Subtopic of Project 863: Molecular Classification and Individualized Diagnosis and Treatment of Common Mental Disorders -- Pilot of Standardization, Integration and Sharing of Genetic Resources of Mental Disorders

• Project of science and technology department of Jilin province: study on correlation between estrogen progesterone receptor gene polymorphism and uterine leiomyoma

• Project of Health Department of Jilin Province: Study on the Relationship between Indoor CO Pollution and Meteorological Conditions and the Early Warning and Forecast of Coal-burning Households in Jilin Province

• Project of Science and Technology Department of Jilin Province. Study on Vulnerability Assessment System of Regional Public Health Emergencies

Publications

• Yang L#, Zhang Y#, Qi W, Zhao T, Zhang L, Zhou L*, Ye L*.Adverse effects of PM2.5 on cardiovascular diseases. Rev Environ Health. 2021 Apr 1. doi: 10.1515/reveh- 2020-0155.

• Guo S#, Zhang B#, Qi W, Cao X, Xu Y, Zhang X, Li X, Zhou L*, Ye L*. Role of estrogen receptor alpha in MEHP-induced proliferation and invasion of SH-SY5Y cells. Toxicology. 2021 Feb 22;453:152734. doi: 10.1016/j.tox.2021.152734. Online ahead of print.

• Shi Y#, Qi W#, Xu Q, Wang Z, Cao X, Zhou L*, Ye L*. The role of epigenetics in the reproductive toxicity of environmental endocrine disruptors. Environ Mol Mutagen. 2021 Jan;62(1):78-88.

• Qi W, Xu Q, Xu Y, Wang Z, Yang L, Guo S, Shi Y, Zhao T, Zhou L*, Ye L*. Effect of Notch pathway on lipid accumulation induced by mono-2-ethylhexyl phthalate on 3T3-L1 cells. Ecotoxicol Environ Saf. 2021 Jan 15;208:111472.

• Xu Q, Qi W, Zhang Y, Wang Q, Ding S, Han X, Zhao Y, Song X, Zhao T, Zhou L*, Ye L*. DNA methylation of JAK3/STAT5/PPARγ regulated the changes of lipid levels induced by di (2-ethylhexyl) phthalate and high-fat diet in adolescent rats. Environ Sci Pollut Res Int. 2020 Aug;27(24):30232-30242.

• Li N, Zhou L, Zhu J, Liu T, Ye L*. Role of the 17β-hydroxysteroid dehydrogenase signalling pathway in di-(2-ethylhexyl) phthalate-induced ovarian dysfunction: An in vivo study. Sci Total Environ. 2020 Apr 10;712:134406.

• Han X#, Gao Y#, Qi W, Ding S, Zhang Y, Xu Q, Zhao Y, Song X, Zhao T, Zhou L*, Ye L*. Arch Environ Occup Health. 2020;75(6):365-370.

• Zhang Y, Zhou L, Zhang Z, Xu Q, Han X, Zhao Y, Song X, Zhao T, Ye L*. Effects of di (2-ethylhexyl) phthalate and high-fat diet on lipid metabolism in rats by JAK2/STAT5. Environ Sci Pollut Res Int. 2020 Feb;27(4):3837-3848.

• Zhang Y, Wang S, Zhao T, Yang L, Guo S, Shi Y, Zhang X, Zhou L*, Ye L*. Mono-2-ethylhexyl phthalate (MEHP) promoted lipid accumulation via JAK2/STAT5 and aggravated oxidative stress in BRL-3A cells. Ecotoxicol Environ Saf. 2019 Nov 30;184:109611.

• Ding S, Zhang Z, Chen Y, Qi W, Zhang Y, Xu Q, Liu H, Zhang T, Zhao Y, Han X, Song X, Zhao T, Ye L*. Urinary levels of phthalate metabolites and their association with lifestyle behaviors in Chinese adolescents and young adults. Ecotoxicol Environ Saf. 2019 Nov 15;183:109541.

• Zhang T#, Zheng Y#, Gao Y, Zhao T, Guo S, Yang L, Shi Y, Zhou L*, Ye L*.Exposure to PM 2.5 affects blood lipid levels in asthmatic rats through notch signaling pathway. Lipids Health Dis. 2019 Aug 7;18(1):160.

• Zhang YZ, Zhang ZM, Zhou LT, Zhu J, Zhang XH, Qi W, Ding S, Xu Q, Han X, Zhao YM, Song XY, Zhao TY, Ye L*. Di (2-ethylhexyl) phthalate Disorders Lipid Metabolism via TYK2/STAT1 and Autophagy in Rats. Biomed Environ Sci. 2019 Jun;32(6):406-418.

• Zhu J, Zhao Y, Gao Y, Li C, Zhou L, Qi W, Zhang Y, Ye L*. Effects of Different Components of PM 2.5 on the Expression Levels of NF-κB Family Gene mRNA and Inflammatory Molecules in Human Macrophage. Int J Environ Res Public Health. 2019 Apr 19;16(8):1408.

• Zhou L, Chen H, Xu Q, Han X, Zhao Y, Song X, Zhao T, Ye L*. The effect of di-2-ethylhexyl phthalate on inflammation and lipid metabolic disorder in rats. Ecotoxicol Environ Saf, 2019, 170: 391-398.

• Zhou L #, Zheng D #, Song X, Zhu J, Qi W, Ding S, Zhang Y, Xu Q, Han X, Zhao Y, Zhao T, Guo S, Shi Y, Yang L, Ye L*. Alternated mRNA expression of the genes in chromosome 9p21 is associated with coronary heart disease and genetic variants in chromosome 9p21. Thromb Res. 2019 Jun;178:17-19.

• Qi W, Zhou L, Zhao T, Ding S, Xu Q, Han X, Zhao Y, Song X, Zhao T, Zhang X, Ye L*. Effect of the TYK-2/STAT-3 pathway on lipid accumulation induced by mono-2-ethylhexyl phthalate. Mol Cell Endocrinol. 2019 Mar 15;484:52-58.

• Zhou L, Liu Y, Chen X, Wang S, Liu H, Zhang T, Zhang Y, Xu Q, Han X, Zhao Y, Song X, Ye L*. Over-expression of nuclear factor-κB family genes and inflammatory molecules is related to chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis, 2018, 13: 2131-2138.

• Yuezhu Zhang, Shuyue Wang, Jian Zhu, Chunyan Li, Tianrong Zhang, Hongbo Liu, Qi Xu, Xiaofang Ye, Liting Zhou*, Lin Ye*, Effect of Atmospheric PM2.5 on Expression Levels of NF-κB Genes and Inflammatory Cytokines Regulated by NF-κB in Human Macrophage, Inflammation. 2018, 41(3): 784-794.

• Di Sun#, Liting Zhou#, Shuyue Wang, Te Liu, Jian Zhu, Yiyang Jia, Jin Xu, Huaiji Chen, Qi Wang, Feng Xu, Yuezhu Zhang, Lin Ye*, Effect of Di-(2-ethylhexyl) phthalate on the hypothalamus-pituitary-thyroid axis in adolescent rat, Endocrine Journal, 2018, 65(3). 261-268.

• Jin Xu#, Liting Zhou#, Shuyue Wang, Jian Zhu, Te Liu, Yiyang Jia, Di Sun, Huaiji Chen, Qi Wang, Feng Xu, Yuezhu Zhang, Hongbo Liu, Tianrong Zhang, Lin Ye*, Di-(2-ethylhexyl)-phthalate induces glucose metabolic disorder in adolescent rats, Environ Sci Pollut Res Int, 2018, 25(4): 3596-3607.

• Li N, Liu T, Guo K, Zhu J, Yu G, Wang S, Ye L*. Effect of mono-(2-ethylhexyl) phthalate (MEHP) on proliferation of and steroid hormone synthesis in rat ovarian granulosa cells in vitro. J Cell Physiol. 2018 Apr;233(4):3629-3637.

• Liting Zhou，Lin Xie，Dongchun Zheng，Na Li，Jian Zhu，Shuyue Wang，Bo Li，Lin Ye*，Genetic Variants of CD40 Gene Are Associated with Coronary Artery Disease and Blood Lipid Levels，BioMed Research International，2016.1693619.

• Liting Zhou, Dongchun Zheng, Shuyue Wang, Jian Zhu, Yiyang Jia, Di Sun, Jin Xu, Qi Wang, Huaiji Chen, Feng Xu, Bo Li*, Lin Ye*. Genetic association of Toll-like receptor 4 gene and coronary artery disease in a Chinese Han population, SpringerPlus, 2016, 5:1533.

• Te Liu#, Yiyang Jia#, Liting Zhou, Qi Wang,Di Sun, Jin Xu, Juan Wu ,Huaiji Chen, Feng Xu, Lin Ye*. Effects of Di-(2-ethylhexyl) Phthalate on the Hypothalamus–Uterus in Pubertal Female Rats. Int J Environ Res Public Health，2016 Nov 12;13(11). pii: E1130.

• Yiyang Jia, Te Liu, Liting Zhou, Jian Zhu, Juan Wu , Di Sun, Jin Xu, Qi Wang, Huaiji Chen, Feng Xu, Yuezhu Zhang, Tianrong Zhang, Hongbo Liu and Lin Ye*.Effects of Di-(2-ethylhexyl) Phthalate on Lipid Metabolism by the JAK/STAT Pathway in Rats. Int J Environ Res Public Health，2016 Nov 4;13(11). pii: E1085.

• Li N#, Liu K#, Yuan H, Zhu J, Yu G, Xie J, Fu S, Guo K, Ye Lin∗. The effect of mono-(2-ethylhexyl) phthalate on apoptosis of rat ovarian granulosa cells in vitro. Environ Toxicol Pharmacol. 2015 Jan 20;39(2):643-650.